RNAseq reveals extensive metabolic disruptions in the sensitive SF-295 cell line treated with schweinfurthins.

For the most parsimonious model (leave-one-out analysis at the distance of one standard error), 6 of 9 genes were significantly different between SF-295 and A549, with one not profiled and one approaching significance (Fig. 3 A).

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Importantly, these data recapitulated much of those in the model generated above, with significant differences between the sensitive SF-295 and insensitive A549 cell lines at baseline including 8 of 14 genes from the fivefold model, with an additional gene nearing significance (Supplementary Fig. 2 ).

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This result may be significant because CDKN2A is commonly mutated in a number of difficult-to-treat cancers, such as glioblastomas and pancreatic ductal adenocarcinomas.

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