The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2.

A modest (1.5-fold) statistically significant (p = 0.0158) increase by the 25 mg/kg dose, and a trend for an increase by the highest (50 mg/kg) dose of PRL-295 was also observed in the kidneys of the animals ( Figure 4 D), although similar to the liver data, the latter was of high inter-individual variation (ranging from 1.4- to 5.2-fold) and did not reach statistical significance (p = 0.1043).

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