G protein-coupled receptor kinase 5 (GRK5) contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure.

We found in the current study that myocardial GRK5 deletion was particularly beneficial for the cardiac contractility of female mice post-MI while male GRK5cKO mice showed a trend towards increase in the EF and towards decrease in the LVIDd when compared to WT mice post-ischemic injury ( Supplementary material online, Figure S30 ).

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