In addition, mIgG1 and mIgG1-N297A tended to increase CD8 and CD4 TILs ( figure 6E , online supplemental figure S8A ), while mIgG2a showed a clear trend towards a decreased CD8:Treg ratio ( figure 6F ).
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Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments.
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