Serum Colorectal Cancer Biomarkers Unraveled by NMR Metabolomics: Past, Present, and Future.

96 conducted an investigation into the 1 H NMR metabolic profile of 44 patient samples with colon polyps and 58 control samples along with numerous demographic parameters, performing seemingly unrelated regression (SUR) for the correlation of the metabolites and the biological groups. They were able to obtain valine as a slightly significant metabolite for patients with polyps, as they had a reduced sample size, but could report 11 groups of metabolites that were significantly different between polyps and control samples. 96 A year later, in 2016, the group of Raftery 97 carried out a metabolomics study using LC-MS and 1 H NMR on serum samples from a positive group for colorectal cancer of 28 subjects, a total of 44 individuals with polyps, and a third group of 55 controls.

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