Human genetic diversity regulating the <i>TLR10/TLR1/TLR6</i> locus confers increased cytokines in response to <i>Chlamydia trachomatis</i>.

trachomatis infection at multiple time points ( Table S2 ), and linear modeling of log 2 [IFNα2] with SNP and 70 h post-infection burden as covariates revealed the SNP effect was much larger (regression coefficient = −0.623 versus 0.017 for burden) and was highly significant, with a p value of 1.87 × 10 −13 (versus p = 0.003 for burden) ( Table S3 ).

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However, we note that the lower IL-6 level in KHV compared to ESN did not reach statistical significance in the linear model, and in our single batch infection described above, the Asian population used (CHS) had greater IL-6 than the LWK population.

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