Seizures in Fragile X Syndrome: Associations and Longitudinal Analysis of a Large Clinic-Based Cohort.

Front Pediatr · 2021 · PMC8756611 · PMID 35036394

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

borderline significancep = 0.058so close (0.05 < p ≤ 0.1)

For females ( N = 23), 18.2% had their first seizure after age 15, a trend in age distribution with borderline significance ( p = 0.058).

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marginally significantp = 0.058so close (0.05 < p ≤ 0.1)

Thus, the marginally significant chi-square ( p = 0.058) for a different male–female distribution of age of seizure onset may be due to the relatively small number of females with seizures in the cohort.

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showed a trendno p-value reported

Studies investigating the association of seizures with other disease features in FXS include a small cohort which showed a trend toward an increased rate of seizures in individuals who were also diagnosed with ASD ( 26 ) and a second small case series of 11 patients which suggested an association between epilepsy and attention problems ( 27 ).

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