Hydroxylation of N-acetylneuraminic Acid Influences the in vivo Tropism of N-linked Sialic Acid-Binding Adeno-Associated Viruses AAV1, AAV5, and AAV6.

Front Med (Lausanne) · 2021 · PMC8757481 · PMID 35036407

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did not reach statistical significanceno p-value reported

For instance, the heart:liver transduction ratios for AAV1, 5 and 6 were 4.6, 6.6, and 8.1-fold higher in WT mice than in CMAH −/− mice, respectively, although the differences did not reach statistical significance.

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Hydroxylation of <i>N</i>-acetylneuraminic Acid Influences the <i>in vivo</i> Tropism of <i>N</i>-linked Sialic Acid-Binding Adeno-Associated Viruses AAV1, AAV5, and AAV6.

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