nominally significantP = 6.4 × 10 −6
5 ) identified an enrichment for rare loss-of-function variants in GRN and indeed, with the second strongest enrichment after GRN ( P = 2.2 × 10 −21 ), we observed a nominally significant enrichment of variants in TET2 in the FTD cohort ( P = 6.4 × 10 −6 ).