With regard to CSF biomarkers, Aβ positivity (A+T + or A+T-) had a negative effect on cognition relative to the control profile A-T- ( p ≤ 0.05), irrespective of tau status, while the effects of tau positivity and Aβ negativity (A-T+) did not reach statistical significance.
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Alzheimer's disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline.
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