Secreted osteopontin from CD4⁺ T cells limits acute graft-versus-host disease.

Despite a weak trend of slightly more WT CD4 + T cells, we did not observe significant differences in the relative frequency of WT and Spp1 −/− CD4 + cells in the colon, SI, spleen, or mesentric lymph node (MLN) on day 7 post transfer ( Figure S4H ).

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The results indicated that recipient-derived OPN contributed to slightly less weight loss ( Figure 2E ), but the change in mouse survival did not reach statistical significance ( Figure 2F ).

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