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Alcohol induced hepatic retinoid depletion is associated with the induction of multiple retinoid catabolizing cytochrome P450 enzymes.

PLoS One · 2022 · PMC8759667 · PMID 35030193

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Interestingly, the induction of Cyp26a1 (~5-fold) in Cyp2e1 -/- mice after alcohol consumption did not reach statistical significance, as compared to the significant induction in WT mice (~15- fold ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.