In recent years, it has been suggested that lifestyle choices may be significant modulators of disease progression.
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Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease.
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This was also reflected in TKV, although the decline in TKV of animals on DCR versus AL did not reach statistical significance; the TKV of study animals at study-start was not significantly different between groups ( Figures S2 D and S2E).