Temporal Transcript Profiling Identifies a Role for Unfolded Protein Stress in Human Gut Ischemia-Reperfusion Injury.

Remarkably, functional analysis of HIF1A targets in the category of biological process showed highly significant enrichment of the GO terms response to unfolded protein ( P < 2.6∗10 -15 ), regulation of cellular response to stress ( P < 2.1∗10 -13 ), and protein folding ( P < 3.0∗10 -13 ) ( Figure 3 B , Supplementary Table 6 ).

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Although the downward trend in apoptosis with increasing ISRIB concentration during reoxygenation did not reach statistical significance in the current experimental setting, these are promising results showing the potential of attenuating hypoxia-reoxygenation–induced cell death via a drastic decrease in pro-apoptotic ATF4/CHOP signaling.

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