Quercetin Attenuates Podocyte Apoptosis of Diabetic Nephropathy Through Targeting EGFR Signaling.

Even though the raise in total EGFR and ERK expression did not reach statistical significance, the expression of phospho-EGFR and phospho-ERK markedly increased in diabetic mice compared with the normal group, and immunohistochemical results showed the same changes Figure 5A, C ), suggesting EGFR was activated under diabetic conditions and quercetin could down-regulate the expressions of phospho-EGFR and phospho-ERK in diabetic mice ( Figure 5B, D ).

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