Thirteen Independent Genetic Loci Associated with Preserved Processing Speed in a Study of Cognitive Resilience in 330,097 Individuals in the UK Biobank.

Genes (Basel) · 2022 · PMC8774848 · PMID 35052462

Europe PMC DOI

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closest p · 0.5× alpha

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nominally significantp = 0.025actually significant

Although no significant genetic loci were found in this analysis and only one of our Resilience genetic loci was nominally significant in the HRS GWAS (chromosome 3 locus; p = 0.025), there was a significant genetic correlation ( r g = −0.65, p = 1.5 × 10 −3 ) between cognitive change and Resilience .

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