Both pulmonary epithelial cell types exhibited visibly increased Tpl2 expression by 3 days post influenza infection by immunohistochemistry ( Fig 1A , middle and bottom panels), and isolated AECI and AECII cells also showed influenza-induced trending increases in Tpl2 expression that did not reach statistical significance ( Fig 1E ).
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Influenza-induced Tpl2 expression within alveolar epithelial cells is dispensable for host viral control and anti-viral immunity.
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