Dual Blockade of TNF and IL-17A Inhibits Inflammation and Structural Damage in a Rat Model of Spondyloarthritis.

Int J Mol Sci · 2022 · PMC8776047 · PMID 35055042

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showed a trendno p-value reported

At the level of the ankle, histological analysis also confirmed a significant reduction of inflammation for the anti-IL17A therapy ( p = 0.047) compared to the vehicle control, while dual blockade and anti-TNF therapies only showed a trend of reduced inflammation ( Figure 2 d), which did not reach significance.

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