Methotrexate Disposition, Anti-Folate Activity, and Metabolomic Profiling to Identify Molecular Markers of Disease Activity and Drug Response in the Collagen-Induced Arthritis Mouse Model.

Metabolites · 2021 · PMC8780148 · PMID 35050146

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did not reach statistical significanceno p-value reported

Among the measures of folate, RBC 5mTHF was found to strongly discriminate based on MTX treatment, while Pl 5mTHF and RBC CH=THF did not reach statistical significance and had much lower AUCs compared to the other biomarkers.

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