Cortisol and development of depression in adolescence and young adulthood - a systematic review and meta-analysis.

Psychoneuroendocrinology · 2022 · PMC8783058 · PMID 34920399

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significancep = .06so close (0.05 < p ≤ 0.1)

After conducting the meta-analysis of cortisol response to stress for these studies, ( Klimes-Dougan et al., 2014 , Ming et al., 2017 , Shenk et al., 2015 ) adolescents with MDD (n = 101) had higher cortisol levels in response to stress compared with adolescents without depression (n = 148), but this did not reach statistical significance (SMD = 0.32, 95% CI −0.01, 0.64, p = .06).

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