Given the exploratory nature of our study and the large number of models for the 6 outcomes and 11 plasma AGEs and oxidation markers, no adjustment for multiplicity was performed, and associations with p values <0.05 were considered nominally significant.
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Plasma advanced glycation end products and the subsequent risk of microvascular complications in type 1 diabetes in the DCCT/EDIC.
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The sentences
However, these associations did not remain significant after adjustment for spot HbA1c, that is, HbA1c closest to TP1, although the MetSOX association that was borderline significant with kidney disease now became significant.
These data are similar (or consistent with) the results of the skin biopsies formerly obtained with only ~200 DCCT participants showing that the long-term risk of complications was highly significant for retinopathy with FL (furosine) and GSPN, kidney disease with FL/GSPN and neuropathy with FL/MG-H1 despite all adjustments.