Hyperpolarised <sup>13</sup>C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer.

The epithelial MCT1 and stromal MCT4 showed a trend that was negative with all the HP 13 C-MRI metabolic parameters, with a significant negative correlation observed between stromal MCT4 and k PL ( P = 0.009; Fig. 2b , Supplementary Table 3 ).

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In contrast, despite an apparent trend, no significant difference in MCT1 expression was seen between low and high %GP4 lesions (Fig. 3b , Supplementary Table 5 ).

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