SARS-CoV-2 N Protein Induces Acute Kidney Injury via Smad3-Dependent G1 Cell Cycle Arrest Mechanism.

Adv Sci (Weinh) · 2022 · PMC8787402 · PMID 34813685

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Interestingly, compared to Smad3 WT mice, mice lacking Smad3 showed a trend increase in renal SARS‐CoV‐2 N mRNA expression although AKI was prevented (Figure 5C ), confirming an essential role for Smad3 in SARS‐CoV‐2 N‐induced AKI. 2.4.

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