• Action potentials showed a trend of dampened sensitivity to adrenergic stimulation when myocytes were paced at physiological frequencies compared to the response seen during commonly used 1 Hz pacing. • This work provides novel reference data demonstrating the range of ventricular action potential adaptation under simulated physiological conditions. 1.
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Action potential responses to changes in stimulation frequency and isoproterenol in rat ventricular myocytes.
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