Longitudinal High-Throughput Sequencing of the T-Cell Receptor Repertoire Reveals Dynamic Change and Prognostic Significance of Peripheral Blood TCR Diversity in Metastatic Colorectal Cancer During Chemotherapy.

Front Immunol · 2021 · PMC8789675 · PMID 35095836

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closest p · 1.4× alpha

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did not reach statistical significancep = 0.07so close (0.05 < p ≤ 0.1)

Similarly, TCRβ repertoires showed an association trend between TCR diversity and the tumor reduction rate ( Figure 5C ), although the sample sizes were limited and did not reach statistical significance (p = 0.07).

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