Comprehensive summary of mitochondrial DNA alterations in the postmortem human brain: A systematic review.

113 , 114 Additionally, although most reports showed a trend or reported increased mtDNA deletion levels in PD, others did not. 109 , 115 Notably, mtDNA deletion levels have been reported to be significantly lower in the cerebellum than in other brain regions. 112 , 116 One of the most recent studies found that patients with PD tended to exhibit deletion levels greater than 60% in the substantia nigra, while markedly lower levels were found in the frontal cortex, cerebellum and putamen.

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