Pan-Cancer Analysis Shows Enrichment of Macrophages, Overexpression of Checkpoint Molecules, Inhibitory Cytokines, and Immune Exhaustion Signatures in EMT-High Tumors.

Front Oncol · 2021 · PMC8790577 · PMID 35096592

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highly significantno p-value reported

Comparing these checkpoint genes among the three EMT groups showed a highly significant difference for almost all cancer types, with EMT-high samples having the highest expression ( Figures 5B–E ).

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showed a trendno p-value reported

Epithelial–Mesenchymal Transition-High Tumors Are Enriched in Inflammation, Exhausted CD8+ T Cells, and Activated Stroma Signatures Analysis of gene signatures showed a trend toward increased inflammation and exhaustion in EMT-high tumors.

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