Consistently, the expression of Gh in the pituitary gland was significantly reduced in Pw1 +/pat- males as compared to Pw1 +/+ littermates, whereas growth hormone receptor ( Ghr ) and Igf1 expression levels in the liver also showed a trend of down-regulation ( Fig 2C ).
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Paternally expressed gene 3 (Pw1/Peg3) promotes sexual dimorphism in metabolism and behavior.
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