We focused on the response to IFN-γ plus CD40L, as these stimuli result in a highly significant difference in TNF-α production between NFAM1 +/+ and NFAM1 -/- monocytes.
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NFAM1 Promotes Pro-Inflammatory Cytokine Production in Mouse and Human Monocytes.
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The sentences
We observed a trend towards decreased TNF-α production with the TLR4 ligand LPS and the dectin-1 ligand depleted zymosan ( Figures 4D, F ), but these differences did not reach statistical significance.