Epistatic models predict mutable sites in SARS-CoV-2 proteins and epitopes.

Proc Natl Acad Sci U S A · 2022 · PMC8795541 · PMID 35022216

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closest p

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a clear trendno p-value reported

Apart from an overall agreement between the three quantities, there is a clear trend for lower values in the core of the RBD and higher in the exposed parts of the structure, probably related to the greater impact of mutations on the stability in the core and the selective pressure for immune escape in the surface.

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