Overcoming PD-1 Blockade Resistance with CpG-A Toll-Like Receptor 9 Agonist Vidutolimod in Patients with Metastatic Melanoma.

Cancer Discov · 2021 · PMC8799774 · PMID 34326162

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In contrast, patients with PD showed a trend toward lower induction of IFN-regulated serum CXCL10 compared with patients with CR/PR/SD, and three of four patients with PD and baseline and on-treatment biopsies showed no increase in tumor IFNγ gene signature.

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