The polymorphisms of extracellular matrix-remodeling genes are associated with pelvic organ prolapse.

They also showed a trend toward significance with POP in the unadjusted model (for both, OR, 1.87; 95% CI, 0.94–3.77; P = 0.076). rs402007, rs428785, rs434857, and rs445784 were respectively significantly associated with POP in the adjusted model (for all, OR, 2.18; 95% CI, 1.05–4.56; P = 0.038). rs402007 was in the 5’UTR region of the ADAMTS1 gene. rs428785 was a missense SNP. rs434857 and rs445784 were synonymous SNPs that did not lead to amino acid changes.

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These SNPs were additionally described in detail in Table 2 and were all in Hardy-Weinberg equilibrium as they reached 10 −6 [ 19 ]. In the analysis of the MMP family genes, we have identified a trend toward significance for MMP9 SNP rs3918254 and POP (OR, 2.21; 95% CI, 0.91–5.36; P = 0.079) after the adjustment, which was an intronic SNP.

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Additionally, we have found two new MMP13 SNPs, rs3758853 and rs78356340, which showed borderline significant associations with POP and may have a risk effect for POP.

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