Distinct Aging-Vulnerable and -Resilient Trajectories of Specific Motor Circuit Functions in Oxidation- and Temperature-Stressed <i>Drosophila</i>.

Across the life span of WT flies, we noted a clear trend of increasing DLM firing rates, which nearly doubled in the oldest flies examined [ Fig. 1 D , E ; Spearman rank correlation coefficient ( r s ) = 0.46, p = 9.9 × 10 −4 , and r s = 0.58, p = 3.6 × 10 −4 , respectively, for 25°C-reared and 29°C-reared flies].

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Over a large portion of the life span, including the oldest flies (95% mortality), WT flies reared at both 25°C and at 29°C did not show a clear trend of increase or decrease in either SLR latency or threshold, but a decreasing trend in both threshold and latency was noted in Sod mutant flies, indicating a consequence of chronic oxidative stress ( Figs. 2 C , 7 B 1,2 ).

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