Mechano-regulated cell-cell signaling in the context of cardiovascular tissue engineering.

There is a clear trend of a higher repopulation on the ventricular side of the valve compared to the pulmonary or aortic side ( Theodoridis et al. 2015 ; Tudorache et al. 2016 ; Reimer et al. 2017 ; Hennessy et al. 2017 ; Goecke et al. 2018 ), as well as a higher cell density in the base and middle of the leaflets compared to the tip ( Theodoridis et al. 2015 ; Syedain et al. 2015 ; Tudorache et al. 2016 ; Miller et al. 2016 ; Goecke et al. 2018 ; Motta et al. 2018 , 2019 ).

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