PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.

Nat Commun · 2022 · PMC8807747 · PMID 35105861

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closest p · 2.8× alpha

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did not reach statistical significanceP = 0.14not close (p > 0.1)

IUE of full-length PPM1D ( PPM1D FL) with H3.3 K27M and Pdgfra D842V plasmids displayed a trend for shortened latency compared to control conditions but did not reach statistical significance (median survival 51 vs. 63 days postnatal, ns, P = 0.14, log-rank Mantle-Cox test) (Supplementary Fig. 3A ).

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