Intra-articular placebo effect in the treatment of knee osteoarthritis: a survey of the current clinical evidence.

11 However, in the trial conducted in China, the primary efficacy endpoint of change in WOMAC A1 from baseline to 26 weeks between the IA HA and the placebo did not reach statistical significance (IA HA −2.146 versus IA saline −2.271; p = 0.36). 12 Authors of the Chinese study attributed this finding to an inflated placebo response that led to nonstatistically significant difference between IA HA and IA saline.

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