Allele-specific transcription factor binding in a cellular model of orofacial clefting.

Further analyses outside of established GWAS risk loci identified 18 SNPs with allele-specific TFAP2A binding, but again, none of them showed a nominally significant association with nsCL/P.

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We observed a highly significant co-localization, with 1333 of the 2845 hc-peaks overlapping at a minimum of one site ( P χ2 < 0.0001, Supplementary Table S5 , Fig. 3 ), indicative of plausibility of the ChIP-seq peaks in HEPM.

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