A Novel 2-Carbon-Linked Dimeric Artemisinin With Potent Antileukemic Activity and Favorable Pharmacology.

In the MV4;11 xenograft model, 9 of 10 mice from the ART631-containing SAV group had undetectable AML burdens on day 98 ( Figure 7B ), compared with 5 of 9 mice from the ART838-containing SAV group ( 20 ); however, the increase in survival in the ART631-containing SAV group compared with the ART838-containing SAV group did not reach statistical significance (p=0.112).

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