Myocardial Rev-erb-Mediated Diurnal Metabolic Rhythm and Obesity Paradox.

Mitochondrial DNA copy numbers and protein content of oxidative phosphorylation complexes remained largely unchanged between KO and WT heart at 10 weeks of age ( Figure S8A and S8B ), whereas the respiratory enzyme activity of succinate dehydrogenase showed a trend of reduction in KO hearts ( Figure S8C ), suggesting that Rev-erb regulates more transient changes in mitochondrial metabolic pathways, although mitochondrial content or biogenesis might be secondarily affected.

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