Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease.

Proc Natl Acad Sci U S A · 2022 · PMC8812691 · PMID 35086928

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a strong trendno p-value reported

However, GA showed a strong trend of diminished mHTT levels, particularly evident with polyQ antibodies in both cell types, and the diminishing effect of GA appeared more pronounced in the human HD fibroblast ( Fig. 7 B and D ).

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highly significantno p-value reported

This result indicated that SUMO1 deletion in Q175DN-het mice delays the rotarod deficit by 6 mo, which is highly significant.

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