In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype.

Examination of our data revealed that transcript levels for two high affinity IgG receptors, FCGR1A and FCGR1B were upregulated 6.92- and 9.96-fold respectively following IFN-γ administration ( Fig 4 , S1 Table , and Table 1 ) and that the time and dose dependences were highly significant.

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The response for p47 phox was delayed in comparison with small early changes at 24 hours and the higher levels at 48 hours approaching significance.

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