Interplay between soluble CD74 and macrophage-migration inhibitory factor drives tumor growth and influences patient survival in melanoma.

When patients were divided into two groups according to the optimal cutoff values of sCD74 and MIF determined by ROC analyses (7.76 ng/mL for sCD74, and 264.59 pg/mL for MIF), patients with high sCD74 and low MIF levels had better OS compared with those with low sCD74 and high MIF levels, respectively, although these differences did not reach statistical significance (Fig. 1H, I ).

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