Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases.

Of note, while AChRγ mRNA showed a trend toward upregulation (Fig. 3 a), histological NMJ denervation was not observed in fast-twitch EDL muscles (Fig. 3 d,e), suggesting that denervation of NMJs occurs predominantly in slow fibers as a consequence of TFG deletion in the innervating nerves.

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