Intake of artificial sweeteners among adults is associated with reduced odds of gastrointestinal luminal cancers: a meta-analysis of cohort and case-control studies.

ll association.[ 37 ] There also has been no consistent association between AS or diet beverages and pancreatic cancer after adjusting for relevant confounders, including sugar-sweetened beverages and obesity, which is confirmed by our meta-analysis; although, one case-control study did demonstrate a suggestive trend for AS and reduced odds of pancreatic cancer (adjusted OR 0.62, 95% CI: 0.37–1.04), which was significant for individuals at least 60 years old and also among those with caloric intakes ≥2100 calories/day (study-specific caloric intake threshold per Bosetti et al. ).[ 21 ] Notably, long-term consumption of sugar-sweetened but not artificially sweetened beverages has been associated with increased risk of cancer-related mortality.[ 60 ] While we excluded analyses of cancer-related mortality, no study in our search analyzed GI cancer-related mortality specifically.

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