At 8 wk after treatment, either ruxolitinib or obatoclax alone, or a combination of both showed a trend, but failed to significantly reduce Hb/Ht, WBC and PLT (Figure 5B‐D ).
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Suppression of multiple anti-apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms.
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