Role of Canonical Wnt/β-Catenin Pathway in Regulating Chondrocytic Hypertrophy in Mesenchymal Stem Cell-Based Cartilage Tissue Engineering.

Front Cell Dev Biol · 2022 · PMC8820467 · PMID 35141220

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In the study by Lee et al., MSCs cultured in 3D chondrogenic combinatorial system with 40% strain showed a trend toward hypertrophic chondrocytes, indicated by the high level of RUNX2, which was also accompanied with more YAP expression ( Lee et al., 2020 ).

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