Barely Significant
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Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control study.

Ann Med · 2022 · PMC8820810 · PMID 35114859

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did not reach statistical significanceno p-value reported
Similar findings were observed when the analysis was stratified by the type of NSAID: non-aspirin NSAIDs [ S = 3.42 (95%CI: 1.12–10.47), RERI = 3.97 (95%CI: 0.44, 7.50)] and aspirin [ S = 7.65 (95%CI: 0.81, 72.33), RERI = 8.39 (95%CI: −4.20, 20.99)], though the interaction estimates did not reach statistical significance in aspirin category probably due to the limited number of aspirin users. rs4809957:A>G: Substantially higher ORs of UGIH were observed for patients carrying rs4809957:A>G who are on treatment involving any NSAID [OR wild-type: 4.12 (95%CI: 2.18–7.79) vs.

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