CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis.

Fluids Barriers CNS · 2022 · PMC8822708 · PMID 35135557

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approaching significanceno p-value reported

Stable RRMS patients not receiving DMT ( r = 0.46, r 2 = 0.21, and p = 0.09) and stable RRMS patients receiving ocrelizumab ( r = 0.50, r 2 = 0.25, p = 0.07) both demonstrated a moderate correlation approaching significance.

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a trend towards significanceno p-value reported

When examining CNS-EEV31 concentrations, active RRMS patients had significantly higher concentrations than stable RRMS patients not receiving DMT, stable RRMS patients receiving natalizumab, and a trend towards significance compared to HC.

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