Heterologous Immunity Between SARS-CoV-2 and Pathogenic Bacteria.

Front Immunol · 2022 · PMC8829141 · PMID 35154139

Europe PMC DOI

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0.0600

closest p · 1.2× alpha

0.1250

boldest claim

The sentences

did not reach statistical significancep=0.06so close (0.05 < p ≤ 0.1)

IFN-γ responses were significantly increased with KP2 and SA1 primed CD8+ T cells whereas SE1 primed cells did not reach statistical significance (p=0.06).

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failed to reach significancep=0.1250not close (p > 0.1)

Potential Anti-Viral Response in CD8+ Cells We found that in CD8+ T cells primed with pathogenic bacterial-derived peptides KP1, KP2 and SE1 had a significantly increased perforin expression upon SARS-CoV-2 restimulation when compared with control primed cells, whereas SA1, CD1 and CL1 failed to reach significance (p=0.1250, 0.06 and 0.06, respectively) ( Figures 3E, F ).

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