Transcription factor regulation of eQTL activity across individuals and tissues.

PLoS Genet · 2022 · PMC8830792 · PMID 35100260

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hedged sentences

0.0500

closest p · 1.0× alpha

0.0600

boldest claim

The sentences

nominally significantp < 0.05actually significant

We discovered 87 nominally significant genes with differing ASE between IRF1 conditions (Fisher’s exact test p < 0.05).

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a small trendp = 0.06so close (0.05 < p ≤ 0.1)

Both cross-tissue and within-tissue expression-based datasets were significantly enriched for ChIP-seq overlap (cross-tissue enrichment statistic = 0.024, p < 2x10 -4 ; within-tissue enrichment statistic = 0.088, p = 2x10 -4 ), and cross-tissue expression-based TF-eQTLs showed a small trend of motif matching enrichment (enrichment statistic = 0.002, p = 0.06) (Figs 3A and S13 ).

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